Izopenicilin-N epimeraza
Izopenicilin-N epimeraza (EC 5.1.1.17, Isopenicillin-N epimerase) je enzim sa sistematskim imenom penicilin-N 5-amino-5-karboksipentanoil-epimeraza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- izopenicilin N penicilin N
Ovaj enzim sadrži piridoksal fosfat.
Reference
- ^ Usui, S. & Yu, C.-A. (1989). „Purification and properties of isopenicillin-N epimerase from Streptomyces clavuligerus”. Biochim. Biophys. Acta. 999: 78—85. PMID 2804141.
- ^ Laiz, L., Liras, P., Castro, J.M. and Martín, J.F. (1990). „Purification and characterization of the isopenicillin-N epimerase from Nocardia lactamdurans”. J. Gen. Microbiol. 136: 663—671.
- ^ Cantwell, C., Beckmann, R., Whiteman, P., Queener, S.W. and Abraham, E.P. (1992). „Isolation of deacetoxycephalosporin-c from fermentation broths of Penicillium chrysogenum transformants - construction of a new fungal biosynthetic-pathway”. Proc. R. Soc. Lond. B Biol. Sci. 248: 283—289. PMID 1354366.
- ^ Yeh, W.K., Ghag, S.K. and Queener, S.W. (1992). „Enzymes for epimerization of isopenicillin N, ring expansion of penicillin N, and 3′-hydroxylation of deacetoxycephalosporin C. Function, evolution, refolding, and enzyme engineering”. Ann. N.Y. Acad. Sci. 672: 396—408.
Literatura
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