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Indol-3-glicerol-fosfatna lijaza
Indol-3-glicerol-fosfatna lijaza
Identifikatori
EC broj	4.1.2.8
CAS broj	9014-52-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Indol-3-glicerol-fosfatna lijaza (EC 4.1.2.8, triptofan sintaza alfa, TSA, indolglicerolfosfat aldolaza, indol glicerol fosfat hidrolaza, indol sintaza, indol-3-glicerolfosfat D-gliceraldehid-3-fosfat-lijaza, indol-3-glicerol fosfat lijaza, IGL, BX1, (1S,2R)-1-C-(indol-3-il)glicerol 3-fosfat D-gliceraldehid-3-fosfat-lijaza) je enzim sa sistematskim imenom (1S,2R)-1-C-(indol-3-il)glicerol-3-fosfat D-gliceraldehid-3-fosfat-lijaza (formira indol).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1S,2R)-1-C-(indol-3-il)glicerol 3-fosfat

\rightleftharpoons

indol + D-gliceraldehid 3-fosfat

Ovaj enzim učestvuje u odbrambenom mehanizmu protiv insekata i mikrobnih patogena u familiji trave, Graminae.

Reference

^ Yanofsky, C. (1956). „The enzymatic conversion of anthranilic acid to indole”. J. Biol. Chem. 223: 171—184. PMID 13376586.
^ Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A. (1997). „Analysis of a chemical plant defense mechanism in grasses”. Science. 277: 696—699. PMID 9235894.
^ Frey, M., Stettner, C., Paré, P.W., Schmelz, E.A., Tumlinson, J.H. and Gierl, A. (2000). „An herbivore elicitor activates the gene for indole emission in maize”. Proc. Natl. Acad. Sci. USA. 97: 14801—14806. PMID 11106389.
^ Melanson, D., Chilton, M.D., Masters-Moore, D. and Chilton, W.S. (1997). „A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize”. Proc. Natl. Acad. Sci. USA. 94: 13345—13350. PMID 9371848.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Indole-3-glycerol-phosphate+lyase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Yanofsky, C. (1956). „The enzymatic conversion of anthranilic acid to indole”. J. Biol. Chem. 223: 171—184. PMID 13376586.

[2] Frey, M., Chomet, P., Glawischnig, E., Stettner, C., Grün, S., Winklmair, A., Eisenreich, W., Bacher, A., Meeley, R.B., Briggs, S.P., Simcox, K. and Gierl, A. (1997). „Analysis of a chemical plant defense mechanism in grasses”. Science. 277: 696—699. PMID 9235894.

[3] Frey, M., Stettner, C., Paré, P.W., Schmelz, E.A., Tumlinson, J.H. and Gierl, A. (2000). „An herbivore elicitor activates the gene for indole emission in maize”. Proc. Natl. Acad. Sci. USA. 97: 14801—14806. PMID 11106389.

[4] Melanson, D., Chilton, M.D., Masters-Moore, D. and Chilton, W.S. (1997). „A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize”. Proc. Natl. Acad. Sci. USA. 94: 13345—13350. PMID 9371848.

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