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Holest-5-en-3b,7a-diol 3b-dehidrogenaza
Holest-5-en-3b,7a-diol 3b-dehidrogenaza
Identifikatori
EC broj	1.1.1.181
CAS broj	56626-16-5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
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Holest-5-en-3b,7a-diol 3b-dehidrogenaza (EC 1.1.1.181, 3beta-hidroksi-Delta5-C27-steroid oksidoreduktaza) je enzim sa sistematskim imenom holest-5-en-3beta,7alfa-diol:NAD⁺ 3-oksidoreduktaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

holest-5-en-3beta,7alfa-diol + NAD⁺

\rightleftharpoons

7alfa-hidroksiholest-4-en-3-on + NADH + H⁺

Holest-5-en-3b,7a-diol 3b-dehidrogenaza je visoko specifična za 3beta-hidroksi-C27-steroide sa Delta5-dvostrukom vezom.

Reference

^ Wikvall, K. (1981). „Purification and properties of a 3β-hydroxy-Δ⁵-C₂₇-steroid oxidoreductase from rabbit liver microsomes”. J. Biol. Chem. 256: 3376—3380. PMID 6937465.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Cholest-5-ene-3beta,7alpha-diol+3beta-dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Wikvall, K. (1981). „Purification and properties of a 3β-hydroxy-Δ⁵-C₂₇-steroid oxidoreductase from rabbit liver microsomes”. J. Biol. Chem. 256: 3376—3380. PMID 6937465.

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