Glutationska hidrolaza

Glutationska hidrolaza
Identifikatori
EC broj3.4.19.13
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Glutationska hidrolaza (EC 3.4.19.13, glutationaza, GGT, gama-glutamiltranspeptidaza) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

glutation + H2O L-cisteinilglicin + L-glutamat

Ovaj protein takođe deluje kao enzim EC 2.3.2.2 (gama-glutamiltransferaza).

Reference

  1. ^ Hanigan, M.H. & Ricketts, W.A. (1993). „Extracellular glutathione is a source of cysteine for cells that express γ-glutamyl transpeptidase”. Biochemistry. 32: 6302—6306. PMID 8099811. 
  2. ^ Suzuki, H. & Kumagai, H. (2002). „Autocatalytic processing of γ-glutamyltranspeptidase”. J. Biol. Chem. 277: 43536—43543. PMID 12207027. 
  3. ^ Okada, T., Suzuki, H., Wada, K., Kumagai, H. and Fukuyama, K. (2006). „Crystal structures of γ-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate”. Proc. Natl. Acad. Sci. USA. 103: 6471—6476. PMID 16618936. 
  4. ^ Boanca, G., Sand, A., Okada, T., Suzuki, H., Kumagai, H., Fukuyama, K. and Barycki, J.J. (2007). „Autoprocessing of Helicobacter pylori γ-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad”. J. Biol. Chem. 282: 534—541. PMID 17107958. 
  5. ^ Okada, T., Suzuki, H., Wada, K., Kumagai, H. and Fukuyama, K. (2007). „Crystal structure of the γ-glutamyltranspeptidase precursor protein from Escherichia coli. Structural changes upon autocatalytic processing and implications for the maturation mechanism”. J. Biol. Chem. 282: 2433—2439. PMID 17135273. 
  6. ^ Wickham, S., West, M.B., Cook, P.F. and Hanigan, M.H. (2011). „Gamma-glutamyl compounds: substrate specificity of γ-glutamyl transpeptidase enzymes”. Anal. Biochem. 414: 208—214. PMID 21447318. 
  7. ^ Carter, B.Z., Wiseman, A.L., Orkiszewski, R., Ballard, K.D., Ou, C.N. and Lieberman, M.W. (1997). „Metabolism of leukotriene C4 in γ-glutamyl transpeptidase-deficient mice”. J. Biol. Chem. 272: 12305—12310. PMID 9139674. 

Literatura

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