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Glutamil-tRNK reduktaza
Glutamil-tRNK reduktaza
Identifikatori
EC broj	1.2.1.70
CAS broj	119940-26-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Glutamil-tRNK reduktaza (EC 1.2.1.70, reduktaza glutamil-tRNK) je enzim sa sistematskim imenom L-glutamat-semialdehid:NADP⁺ oksidoreduktaza (formira L-glutamil-tRNKGlu).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-glutamat 1-semialdehid + NADP⁺ + tRNAGlu

\rightleftharpoons

L-glutamil-tRNAGlu + NADPH + H⁺

Ovaj enzim formira deo puta za biosintezu 5-aminolevulinata iz glutamata, koji je poznat kao C5 put. Njega koriti većina eubakterija, i sve arhebakterije, alge i biljke.

Reference

^ von Wettstein, D., Gough, S. and Kannangara, C.G. (1995). „Chlorophyll biosynthesis”. Plant Cell. 7: 1039—1057. PMID 12242396.
^ Pontoppidan, B. & Kannangara, C.G. (1994). „Purification and partial characterisation of barley glutamyl-tRNA^Glu reductase, the enzyme that directs glutamate to chlorophyll biosynthesis”. Eur. J. Biochem. 225: 529—537. PMID 7957167.
^ Schauer, S., Chaturvedi, S., Randau, L., Moser, J., Kitabatake, M., Lorenz, S., Verkamp, E., Schubert, W.D., Nakayashiki, T., Murai, M., Wall, K., Thomann, H.-U., Heinz, D.W., Inokuchi, H, Söll, D. and Jahn, D. (2002). „Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate”. J. Biol. Chem. 277: 48657—48663. PMID 12370189.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Glutamyl-tRNA+reductase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] von Wettstein, D., Gough, S. and Kannangara, C.G. (1995). „Chlorophyll biosynthesis”. Plant Cell. 7: 1039—1057. PMID 12242396.

[2] Pontoppidan, B. & Kannangara, C.G. (1994). „Purification and partial characterisation of barley glutamyl-tRNA^Glu reductase, the enzyme that directs glutamate to chlorophyll biosynthesis”. Eur. J. Biochem. 225: 529—537. PMID 7957167.

[3] Schauer, S., Chaturvedi, S., Randau, L., Moser, J., Kitabatake, M., Lorenz, S., Verkamp, E., Schubert, W.D., Nakayashiki, T., Murai, M., Wall, K., Thomann, H.-U., Heinz, D.W., Inokuchi, H, Söll, D. and Jahn, D. (2002). „Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate”. J. Biol. Chem. 277: 48657—48663. PMID 12370189.

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