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Glukuronozil-N-acetilglukozaminil-proteoglikan 4-a-N-acetilglukozaminiltransferaza
Glukuronozil-N-acetilglukozaminil-proteoglikan 4-a-N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.224
CAS broj	336193-98-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Glukuronozil-N-acetilglukozaminil-proteoglikan 4-a-N-acetilglukozaminiltransferaza (EC 2.4.1.224, alfa-N-acetilglukozaminiltransferaza II glukuronil-N-acetilglukozaminilproteoglikan alfa-1,4-N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-proteoglikan 4-alfa-N-acetilglukozaminiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-proteoglikan

\rightleftharpoons

UDP + N-acetil-alfa-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->4)-N-acetil-alfa-D-glukozaminil-proteoglikan

Ovaj enzim učestvuje u inicijaciji sinteze heparina i heparan sulfata.

Reference

^ Kim, B.T., Kitagawa, H., Tamura, J., Saito, T., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4-N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis”. Proc. Natl. Acad. Sci. USA. 98: 7176—7181. PMID 11390981.
^ Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate”. J. Biol. Chem. 276: 4834—4838. PMID 11121397.
^ Senay, C., Lind, T., Muguruma, K., Tone, Y., Kitagawa, H., Sugahara, K., Lidholt, K., Lindahl, U. and Kusche-Gullberg, M. (2000). „The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis”. EMBO Rep. 1: 282—286. PMID 11256613.
^ Lind, T., Tufaro, F., McCormick, C., Lindahl, U. and Lidholt, K. (1998). „The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate”. J. Biol. Chem. 273: 26265—26268. PMID 9756849.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Glucuronosyl-N-acetylglucosaminyl-proteoglycan+4-alpha-N-acetylglucosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kim, B.T., Kitagawa, H., Tamura, J., Saito, T., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode α1,4-N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/heparin biosynthesis”. Proc. Natl. Acad. Sci. USA. 98: 7176—7181. PMID 11390981.

[2] Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate”. J. Biol. Chem. 276: 4834—4838. PMID 11121397.

[3] Senay, C., Lind, T., Muguruma, K., Tone, Y., Kitagawa, H., Sugahara, K., Lidholt, K., Lindahl, U. and Kusche-Gullberg, M. (2000). „The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis”. EMBO Rep. 1: 282—286. PMID 11256613.

[4] Lind, T., Tufaro, F., McCormick, C., Lindahl, U. and Lidholt, K. (1998). „The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate”. J. Biol. Chem. 273: 26265—26268. PMID 9756849.

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