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Glukuronozil-N-acetilgalaktozaminil-proteoglikan 4-b-N-acetilgalaktozaminiltransferaza
Glukuronozil-N-acetilgalaktozaminil-proteoglikan 4-b-N-acetilgalaktozaminiltransferaza
Identifikatori
EC broj	2.4.1.175
CAS broj	96189-40-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Glukuronozil-N-acetilgalaktozaminil-proteoglikan 4-b-N-acetilgalaktozaminiltransferaza (EC 2.4.1.175, N-acetilgalaktozaminiltransferaza II, UDP-N-acetil-D-galaktozamin:D-glukuronil-N-acetil-1,3-beta-D-galaktozaminilproteoglikan beta-1,4-N-acetilgalaktozaminiltransferaza, hondroitinska sintaza, glukuronil-N-acetilgalaktozaminilproteoglikan beta-1,4-N-acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-hondroitinska acetilgalaktozaminiltransferaza II) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:beta-D-glukuronazil-(1->3)-N-acetil-beta-D-galaktozaminil-proteoglikan 4-beta-N-acetilgalaktozaminiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-galaktozamin + beta-D-glukuronazil-(1->3)-N-acetil-beta-D-galaktozaminil-proteoglikan

\rightleftharpoons

UDP + N-acetil-beta-D-galaktozaminil-(1->4)-beta-D-glukuronazil-(1->3)-N-acetil-beta-D-galaktozaminil-proteoglikan

Ovaj enzim učestvuje u biosintezi hondroitin sulfata.

Reference

^ Rohrmann, K., Niemann, R. and Buddecke, E. (1985). „Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate”. Eur. J. Biochem. 148: 463—469. PMID 3922754.
^ Kitagawa, H., Uyama, T. and Sugahara, K. (2001). „Molecular cloning and expression of a human chondroitin synthase”. J. Biol. Chem. 276: 38721—38726. PMID 11514575.
^ DeAngelis, P.L. & Padgett-McCue, A.J. (2000). „Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F”. J. Biol. Chem. 275: 24124—24129. PMID 10818104.
^ Ninomiya, T., Sugiura, N., Tawada, A., Sugimoto, K., Watanabe, H. and Kimata, K. (2002). „Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4”. J. Biol. Chem. 277: 21567—21575. PMID 11943778.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Glucuronosyl-N-acetylgalactosaminyl-proteoglycan+4-beta-N-acetylgalactosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Rohrmann, K., Niemann, R. and Buddecke, E. (1985). „Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate”. Eur. J. Biochem. 148: 463—469. PMID 3922754.

[2] Kitagawa, H., Uyama, T. and Sugahara, K. (2001). „Molecular cloning and expression of a human chondroitin synthase”. J. Biol. Chem. 276: 38721—38726. PMID 11514575.

[3] DeAngelis, P.L. & Padgett-McCue, A.J. (2000). „Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F”. J. Biol. Chem. 275: 24124—24129. PMID 10818104.

[4] Ninomiya, T., Sugiura, N., Tawada, A., Sugimoto, K., Watanabe, H. and Kimata, K. (2002). „Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4”. J. Biol. Chem. 277: 21567—21575. PMID 11943778.

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