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Glukuronilgalaktozilproteoglikan 4-b-N-acetilgalaktozaminiltransferaza
Glukuronilgalaktozilproteoglikan 4-b-N-acetilgalaktozaminiltransferaza
Identifikatori
EC broj	2.4.1.174
CAS broj	96189-39-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Glukuronilgalaktozilproteoglikan 4-b-N-acetilgalaktozaminiltransferaza (EC 2.4.1.174, N-acetilgalaktozaminiltransferaza I, glukuronilgalaktozilproteoglikan beta-1,4-N-acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-hondroitin acetilgalaktozaminiltransferaza I, UDP-N-acetil-D-galaktozamin:D-glukuronil-1,3-beta-D-galaktozil-proteoglikan beta-1,4-N-acetilgalaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:D-glukuronil-(1->3)-beta-D-galaktozil-proteoglikan 4-beta-N-acetilgalaktozaminiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-galaktozamin + beta-D-glukuronil-(1->3)-D-galaktozil-proteoglikan

\rightleftharpoons

UDP + N-acetil-D-galaktozaminil-(1->4)-beta-D-glukuronil-(1->3)-beta-D-galaktozilproteoglikan

Za dejstvo ovog enzima je neophodan Mn²⁺.

Reference

^ Rohrmann, K., Niemann, R. and Buddecke, E. (1985). „Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate”. Eur. J. Biochem. 148: 463—469. PMID 3922754.
^ Uyama, T., Kitagawa, H., Tamura, J.-i. and Sugahara, K. (2002). „Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate”. J. Biol. Chem. 277: 8841—8846. PMID 11788602.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Glucuronylgalactosylproteoglycan+4-beta-N-acetylgalactosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Rohrmann, K., Niemann, R. and Buddecke, E. (1985). „Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate”. Eur. J. Biochem. 148: 463—469. PMID 3922754.

[2] Uyama, T., Kitagawa, H., Tamura, J.-i. and Sugahara, K. (2002). „Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate”. J. Biol. Chem. 277: 8841—8846. PMID 11788602.

[1]

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