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Glukuronil-galaktozil-proteoglikan 4-a-N-acetilglukozaminiltransferaza
Glukuronil-galaktozil-proteoglikan 4-a-N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.223
CAS broj	179241-74-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
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Glukuronil-galaktozil-proteoglikan 4-a-N-acetilglukozaminiltransferaza (EC 2.4.1.223, alfa-N-acetilglukozaminiltransferaza I, alfa1,4-N-acetilglukozaminiltransferaza, glukuronazilgalaktozil-proteoglikan 4-alfa-N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-glukuronasil-(1->3)-beta-D-galaktozil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-ksilosil-proteoglikan 4IV-alfa-N-acetil-D-glukozaminiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + beta-D-glukuronazil-(1->3)-beta-D-galaktozil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-ksilozil-proteoglikan

\rightleftharpoons

UDP + alfa-N-acetil-D-glukozaminil-(1->4)-beta-D-glukuronazil-(1->3)-beta-D-galaktozil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-ksilozil-proteoglikan

Ovaj enzim učestvuje u inicijaciji sinteze heparina i heparan sulfata.

Reference

^ Kitagawa, H., Shimakawa, H. and Sugahara, K. (1999). „The tumor suppressor EXT-like gene EXTL2 encodes an α1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate”. J. Biol. Chem. 274: 13933—13937. PMID 10318803.
^ Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate”. J. Biol. Chem. 276: 4834—4838. PMID 11121397.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Glucuronyl-galactosyl-proteoglycan+4-alpha-N-acetylglucosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kitagawa, H., Shimakawa, H. and Sugahara, K. (1999). „The tumor suppressor EXT-like gene EXTL2 encodes an α1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate”. J. Biol. Chem. 274: 13933—13937. PMID 10318803.

[2] Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U. and Sugahara, K. (2001). „rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel α1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate”. J. Biol. Chem. 276: 4834—4838. PMID 11121397.

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