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PubMed	članci
NCBI	proteini

Glikozilkeramidaza
Glikozilkeramidaza
Identifikatori
EC broj	3.2.1.62
CAS broj	2605556
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glikozilkeramidaza (EC 3.2.1.62, florizinska hidrolaza, floretin-glukozidaza, glikozil keramidna glikozilhidrolaza, cerebrozidaza, floridzin beta-glukozidaza, laktaza-florizin hidrolaza, floridzin glukozidaza) je enzim sa sistematskim imenom glikozil-N-acilsfingozin glikohidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

glikozil-N-acilsfingozin + H₂O

\rightleftharpoons

keramid + šećer

Ovaj enzim takođe hidrolizuje florizin do floretina i glukoze.

Reference

^ Leese, H.J. & Semenza, G. (1973). „On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase”. J. Biol. Chem. 248: 8170—8173. PMID 4752949.
^ Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. (1972). „A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase”. Eur. J. Clin. Invest. 2: 326—331. PMID 5082068.
^ Malathi, P. & Crane, R.K. (1969). „Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane”. Biochim. Biophys. Acta. 173: 245—256. PMID 5774775.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Glycosylceramidase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Leese, H.J. & Semenza, G. (1973). „On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase”. J. Biol. Chem. 248: 8170—8173. PMID 4752949.

[2] Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. (1972). „A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase”. Eur. J. Clin. Invest. 2: 326—331. PMID 5082068.

[3] Malathi, P. & Crane, R.K. (1969). „Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane”. Biochim. Biophys. Acta. 173: 245—256. PMID 5774775.

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