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PubMed	članci
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Glikozilfosfatidilinozitolna fosfolipaza D
Glikozilfosfatidilinozitolna fosfolipaza D
Identifikatori
EC broj	3.1.4.50
CAS broj	113756-14-2
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glikozilfosfatidilinozitolna fosfolipaza D (EC 3.1.4.50, GPI-PLD, glikoproteinska fosfolipaza D, fosfatidilinozitolna fosfolipaza D, fosfatidilinozitol-specifična fosfolipaza D) je enzim sa sistematskim imenom glikoprotein-fosfatidilinozitol fosfatidohidrolaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

6-(alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol + H₂O

\rightleftharpoons

6-(alfa-D-glukozaminil)-1D-mio-inozitol + 3-sn-fosfatidat

Ovaj enzim je takođe aktivan kad je O-4 glukozamina supstituisan oligosaharidom.

Reference

^ Low, M.G. & Prasad, A.R.S. (1988). „A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma”. Proc. Natl. Acad. Sci. USA. 85: 980—984. PMID 3422494.
^ Malik, A.-S. & Low, M.G. (1986). „Conversion of human placental alkaline phosphatase from a high M_r form to a low M_r form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases”. Biochem. J. 240: 519—527. PMID 3028377.
^ Li, J.Y., Hollfelder, K., Huang, K.S. and Low, M.G. (1994). „Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca²⁺ binding studies”. J. Biol. Chem. 269: 28963—28971. PMID 7961859.
^ Deeg, M.A, Vierman, E.L. and Cheung, M.C. (2001). „GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex”. J. Lipid Res. 42: 442—451. PMID 11254757.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Glycosylphosphatidylinositol+phospholipase+D на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Low, M.G. & Prasad, A.R.S. (1988). „A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma”. Proc. Natl. Acad. Sci. USA. 85: 980—984. PMID 3422494.

[2] Malik, A.-S. & Low, M.G. (1986). „Conversion of human placental alkaline phosphatase from a high M_r form to a low M_r form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases”. Biochem. J. 240: 519—527. PMID 3028377.

[3] Li, J.Y., Hollfelder, K., Huang, K.S. and Low, M.G. (1994). „Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca²⁺ binding studies”. J. Biol. Chem. 269: 28963—28971. PMID 7961859.

[4] Deeg, M.A, Vierman, E.L. and Cheung, M.C. (2001). „GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex”. J. Lipid Res. 42: 442—451. PMID 11254757.

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