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Glicilpeptid N-tetradekanoiltransferaza
Glicilpeptid N-tetradekanoiltransferaza
Identifikatori
EC broj	2.3.1.97
CAS broj	110071-61-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Glicilpeptid N-tetradekanoiltransferaza (EC 2.3.1.97, peptid N-miristoiltransferaza, miristoil-KoA-protein N-miristoiltransferaza, miristoil-koenzim A:protein N-miristoil transferaza, miristoilacioni enzim, protein N-miristoiltransferaza) je enzim sa sistematskim imenom tetradekanoil-KoA:glicilpeptid N-tetradekanoiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

tetradekanoil-KoA + glicilpeptid

\rightleftharpoons

KoA + N-tetradekanoilglicilpeptid

Enzim iz kvasca je veoma specifičan za tetradekanoil-KoA, za N-terminalni glicin u oligopeptidima koji sadrže serin u 5-pozicija. Enzim iz srca sisara prenosi grupe na specifične 51 kDa akceptorske proteine.

Reference

^ Guertin, D., Gris-Miron, L. and Riendeau, D. (1986). „Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue”. Biochem. Cell Biol. 64: 1249—1255. PMID 3566958.
^ Heuckeroth, R.O., Towler, D.A., Adams, S.P., Glaser, L. and Gordon, J.I. (1988). „11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase”. J. Biol. Chem. 263: 2127—2133. PMID 3123489.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Glycylpeptide+N-tetradecanoyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Guertin, D., Gris-Miron, L. and Riendeau, D. (1986). „Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue”. Biochem. Cell Biol. 64: 1249—1255. PMID 3566958.

[2] Heuckeroth, R.O., Towler, D.A., Adams, S.P., Glaser, L. and Gordon, J.I. (1988). „11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase”. J. Biol. Chem. 263: 2127—2133. PMID 3123489.

[1]

[2]