Gliceril-etar monooksigenaza

Gliceril-etar monooksigenaza
Identifikatori
EC broj1.14.16.5
CAS broj37256-82-9
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Gliceril-etar monooksigenaza (EC 1.14.16.5, gliceril-etarska monooksigenaza, enzim odvajanja gliceril-etra, gliceril etarska oksigenaza, glicerilna eteraza, O-alkilglicerolna monooksigenaza) je enzim sa sistematskim imenom 1-alkil-sn-glicerol,tetrahidrobiopterin:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju:

1-O-alkil-sn-glicerol + tetrahidrobiopterin + O2 1-O-(1-hidroksialkil)-sn-glicerol + dihidrobiopterin + H2O

Ovaj enzim razlaže alkilglicerole. Za njegovo dejstvo je neophodno gvožđe nevezano za hem, redukovani glutation i fosfolipidi.

Reference

  1. ^ Ishibashi, T. & Imai, Y. (1983). „Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes”. Eur. J. Biochem. 132: 23—27. PMID 6840084. 
  2. ^ Pfleger, E.C., Piantadosi, C. and Snyder, F. (1967). „The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species”. Biochim. Biophys. Acta. 144: 633—648. PMID 4383918. 
  3. ^ Snyder, F., Malone, B. and Piantadosi, C. (1973). „Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity”. Biochim. Biophys. Acta. 316: 259—265. PMID 4355017. 
  4. ^ Soodsma, J.F., Piantadosi, C. and Snyder, F. (1972). „Partial characterization of the alkylglycerol cleavage enzyme system of rat liver”. J. Biol. Chem. 247: 3923—3929. PMID 4402391. 
  5. ^ Tietz, A., Lindberg, M. and Kennedy, E.P. (1964). „A new pteridine-requiring enzyme system for the oxidation of glyceryl ethers”. J. Biol. Chem. 239: 4081—4090. PMID 14247652. 
  6. ^ Taguchi, H. & Armarego, W.L. (1998). „Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism”. Med. Res. Rev. 18: 43—89. PMID 9436181. 
  7. ^ Watschinger, K., Keller, M.A., Hermetter, A., Golderer, G., Werner-Felmayer, G. and Werner, E.R. (2009). „Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence”. Biol. Chem. 390: 3—10. PMID 19007315. 
  8. ^ Werner, E.R., Hermetter, A., Prast, H., Golderer, G. and Werner-Felmayer, G. (2007). „Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay”. J. Lipid Res. 48: 1422—1427. PMID 17303893. 

Literatura

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