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Gama-D-glutamil-meso-diaminopimelatna peptidaza
Gama-D-glutamil-meso-diaminopimelatna peptidaza
Identifikatori
EC broj	3.4.19.11
CAS broj	62572-28-5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Gama-D-glutamil-meso-diaminopimelatna peptidaza (EC 3.4.19.11, endopeptidaza I, gama-D-glutamildiaminopimelatna endopeptidaza, gama-D-glutamil-L-meso-diaminopimelatna peptidoglikanska hidrolaza, gama-glutamil-L-meso-diaminopimelilna endopeptidaza, gama-D-glutamil-meso-diaminopimelatna endopeptidaza, gama-D-glutamil-meso-diaminopimelinska peptidoglikanska hidrolaza, gama-D-glutamil-meso-diaminopimelinska endopeptidaza, gama-D-glutamil-meso-D-aminopimelinska endopeptidaza) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

hidroliza gama-D-glutamilnih veza do L-terminusa (pozicije 7) meso-diaminopimelinske kiselina (meso-A2pm) in 7-(L-Ala-gama-D-Glu)-meso-A2pm i 7-(L-Ala-gama-D-Glu)-7-(D-Ala)-meso-A2pm. Neophodno je da D-terminalne amino i karboksi grupe meso-A2pm nisu supstituisane

Ova metalopeptidaza je izolovana iz bakterije Bacillus sphaericus.

Reference

^ Arminjon, F., Guinand, M., Vacheron, M.-J. and Michel, G. (1977). „Specificity profiles of the membrane-bound γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602”. Eur. J. Biochem. 73: 557—565. PMID 849747.
^ Garnier, M., Vacheron, M.-J., Guinard, M. and Michel, G. (1985). „Purification and partial characterization of the extracellular γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602”. Eur. J. Biochem. 148: 539—543. PMID 3922755.
^ Hourdou, M.-L., Guinand, M., Vacheron, M.-J., Michel, G., Denoroy, L., Duez, C., Englebert, S., Joris, B., Weber, G. and Ghuysen, J.-M. (1993). „Characterization of the sporulation-related γ-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein”. Biochem. J. 292: 563—570. PMID 8503890.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Gamma-D-glutamyl-meso-diaminopimelate+peptidase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Arminjon, F., Guinand, M., Vacheron, M.-J. and Michel, G. (1977). „Specificity profiles of the membrane-bound γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602”. Eur. J. Biochem. 73: 557—565. PMID 849747.

[2] Garnier, M., Vacheron, M.-J., Guinard, M. and Michel, G. (1985). „Purification and partial characterization of the extracellular γ-D-glutamyl-(L)meso-diaminopimelate endopeptidase I, from Bacillus sphaericus NCTC 9602”. Eur. J. Biochem. 148: 539—543. PMID 3922755.

[3] Hourdou, M.-L., Guinand, M., Vacheron, M.-J., Michel, G., Denoroy, L., Duez, C., Englebert, S., Joris, B., Weber, G. and Ghuysen, J.-M. (1993). „Characterization of the sporulation-related γ-D-glutamyl-(L)meso-diaminopimelic-acid-hydrolysing peptidase I of Bacillus sphaericus NCTC 9602 as a member of the metallo(zinc) carboxypeptidase A family. Modular design of the protein”. Biochem. J. 292: 563—570. PMID 8503890.

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