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Vezujući protein guaninskog nukleotida, alfa jedinica 3
Vezujući protein guaninskog nukleotida, alfa jedinica 3
Identifikatori
Simboli	GNAT3; GDCA
Vanjski ID	OMIM: 139395 MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3 Gene
Ontologija gena
Molekularna funkcija	• vezivanje G-protein spregnutog receptora; • aktivnost GTPaza; • aktivnost prenosa signala; • GTP vezivanje;
Celularna komponenta	• fotoreceptorski spoljašnje segment; • fotoreceptorski unutrašnji segment; • citoplazma; • heterotrimerni G proteinski kompleks;
Biološki proces	• detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji gorkog ukusa; • GTP katabolički proces; • signalni put adenilat ciklazom modulisanog G protein spregnutog receptora;
Ortolozi
Vrsta	Čovek
Entrez	346562
Ensembl	ENSG00000214415
UniProt	A8MTJ3
RefSeq (mRNA)	NM_001102386.1
RefSeq (protein)	NP_001095856.1
Lokacija (UCSC)	Chr 7:; 80.09 - 80.14 Mb
PubMed pretraga	[1]

Vezujući protein guaninskog nukleotida G(t), alfa jedinica 3 (gustducin alfa-3 lanac) je protein koji je kod ljudi kodiran GNAT3 genom.^[1]

Gustducin alfa-3 lanac je podjedinica heterotrimerinog proteina gustducina koji je odgovoran za osnovne ukuse.

Reference

^ „Entrez Gene: guanine nucleotide binding protein”.

Literatura

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Jang HJ; Kokrashvili Z; Theodorakis MJ; et al. (2007). „Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.”. Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069—74. Bibcode:2007PNAS..10415069J. PMID 17724330. doi:10.1073/pnas.0706890104.
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Fehr J; Meyer D; Widmayer P; et al. (2007). „Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.”. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 193 (1): 21—34. PMID 17021831. doi:10.1007/s00359-006-0168-8.
Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). „Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.”. Nature. 369 (6482): 621—8. PMID 8208289. doi:10.1038/369621a0.

[entrez-1] „Entrez Gene: guanine nucleotide binding protein”.

[1]