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Fosfatidilinozitolna diacilglicerol-lijaza
Fosfatidilinozitolna diacilglicerol-lijaza
Identifikatori
EC broj	4.6.1.13
CAS broj	37288-19-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Fosfatidilinozitolna diacilglicerol-lijaza (EC 4.6.1.13, monofosfatidilinozitol fosfodiesteraza, fosfatidilinozitol fosfolipaza C, 1-fosfatidilinozitol fosfodiesteraza, 1-fosfatidil-D-mio-inozitol inozitolfosfohidrolaza (formira ciklična-fosfat), 1-fosfatidil-1D-mio-inozitol diacilglicerol-lijaza (formira 1,2-ciklična-fosfat)) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol 1,2-diacil-sn-glicerol-lijaza (formira 1D-mio-inozitol-1,2-ciklična-fosfat).^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-fosfatidil-1D-mio-inozitol

\rightleftharpoons

1D-mio-inozitol 1,2-ciklični fosfat + 1,2-diacil-sn-glicerol

Ovaj enzim je bakterijskog porekla.

Reference

^ Allan, D. & Michell, R.H. (1974). „Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes”. Activity at pH5.5 and pH7.0. Biochem. J. 142: 591—597. PMID 4377210.
^ Friedel, R.O., Brown, J.D. and Durell, J. (1967). „Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain”. Biochim. Biophys. Acta. 144: 684—686. PMID 4294905.
^ Irvine, R.F. (1982). „The enzymology of stimulated inositol lipid turnover”. Cell Calcium. 3: 295—309. PMID 6297738.
^ Michell, R.H. & Allan, D. (1975). „Inositol cyclic phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)”. FEBS Lett. 53: 302—304. PMID 236918.
^ Low, M.G. & Finean, J.B. (1977). „Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C”. Biochem. J. 167: 281—284. PMID 588258.
^ Henner, D.J., Yang, M., Chen, E., Helmikss, R. and Low, M.G. (1988). „Sequence of the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C”. Nucleic Acids Res. 16: 10383—10383. PMID 3194218.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Phosphatidylinositol+diacylglycerol-lyase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Allan, D. & Michell, R.H. (1974). „Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes”. Activity at pH5.5 and pH7.0. Biochem. J. 142: 591—597. PMID 4377210.

[2] Friedel, R.O., Brown, J.D. and Durell, J. (1967). „Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain”. Biochim. Biophys. Acta. 144: 684—686. PMID 4294905.

[3] Irvine, R.F. (1982). „The enzymology of stimulated inositol lipid turnover”. Cell Calcium. 3: 295—309. PMID 6297738.

[4] Michell, R.H. & Allan, D. (1975). „Inositol cyclic phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)”. FEBS Lett. 53: 302—304. PMID 236918.

[5] Low, M.G. & Finean, J.B. (1977). „Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C”. Biochem. J. 167: 281—284. PMID 588258.

[6] Henner, D.J., Yang, M., Chen, E., Helmikss, R. and Low, M.G. (1988). „Sequence of the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C”. Nucleic Acids Res. 16: 10383—10383. PMID 3194218.

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