Endo-alfa-sijalidaza

Endo-alfa-sijalidaza
Identifikatori
EC broj3.2.1.129
CAS broj91195-87-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Endo-alfa-sijalidaza (EC 3.2.1.129, endo-N-acilneuraminidaza, endoneuraminidaza, endo-N-acetilneuraminidaza, poli(alfa-2,8-sijalozil) endo-N-acetilneuraminidaza, poli(alfa-2,8-sijalozid) alfa-2,8-sijalozilhidrolaza, endosijalidaza, endo-N) je enzim sa sistematskim imenom polisijalozid (2->8)-alfa-sijalozilhidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endohidroliza (2->8)-alfa-sijalozil veza u oligo- ili poli(sijaliskoj) kiselini

Dejstvo ovog enzima je ograničeno na acetilisane supstrate.

Reference

  1. ^ Finne, J., Mäkelä, P.H. (1985). „Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid”. J. Biol. Chem. 260: 1265—1270. PMID 3968060. 
  2. ^ Hallenbeck, P.C., Vimr, E.R., Yu, F., Bassler, B. and Troy, F.A. (1987). „Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-α-2,8-sialosyl carbohydrate units”. J. Biol. Chem. 262: 3553—3561. PMID 3546309. 
  3. ^ Kitakima, K., Inoue, S., Inoue, Y. and Troy, F.A. (1988). „Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies”. J. Biol. Chem. 263: 18269—18276. PMID 3142874. 
  4. ^ Kwiatkowski, B., Boscheck, B., Thicle, H. and Stirm, S. (1982). „Endo-N-acetylneuraminidase associated with bacteriophage particles”. J. Virol. 43: 697—704. PMID 7109038. 
  5. ^ Pelkonen, S., Pelkonen, J. and Finne, J. (1989). „Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins”. J. Virol. 65: 4409—4416. PMID 2778882. 
  6. ^ Tombinson, S. & Taylor, P.W. (1985). „Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide”. J. Virol. 55: 374—378. PMID 3894684. 
  7. ^ Cabezas, J.A. (1991). „Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase”. Biochem. J. 278: 311—312. PMID 1883340. 

Literatura

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