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Ekso-1,4-beta-D-glukozaminidaza
Ekso-1,4-beta-D-glukozaminidaza
Identifikatori
EC broj	3.2.1.165
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Ekso-1,4-beta-D-glukozaminidaza (EC 3.2.1.165, CsxA, GlcNaza, eksohitozanaza, GlmA, ekso-beta-D-glukozaminidaza, hitozan ekso-1,4-beta-D-glukozaminidaza) je enzim sa sistematskim imenom hitozan ekso-(1->4)-beta-D-glukosaminidaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

hidroliza hitozana ili hitozan oligosaharida čime se sukcesivno odvajaju D-glukozaminski ostataci sa neredukujućeg kraja

Hitozan je parcijalno ili totalno N-deacetilisan hitinski derivat koji je prisutan u ćelijskim zidovima pojedinih fitopatogenih gljiva.

Reference

^ Nanjo, F., Katsumi, R. and Sakai, K. (1990). „Purification and characterization of an exo-β-D-glucosaminidase, a novel type of enzyme, from Nocardia orientalis”. J. Biol. Chem. 265: 10088—10094. PMID 2351651.
^ Nogawa, M., Takahashi, H., Kashiwagi, A., Ohshima, K., Okada, H. and Morikawa, Y. (1998). „Purification and characterization of exo-β-D-glucosaminidase from a cellulolytic fungus, Trichoderma reesei PC-3-7”. Appl. Environ. Microbiol. 64: 890—895. PMID 16349528.
^ Fukamizo, T., Fleury, A., Côté, N., Mitsutomi, M. and Brzezinski, R. (2006). „Exo-β-D-glucosaminidase from Amycolatopsis orientalis: catalytic residues, sugar recognition specificity, kinetics, and synergism”. Glycobiology. 16: 1064—1072. PMID 16877749.
^ Côté, N., Fleury, A., Dumont-Blanchette, E., Fukamizo, T., Mitsutomi, M. and Brzezinski, R. (2006). „Two exo-β-D-glucosaminidases/exochitosanases from actinomycetes define a new subfamily within family 2 of glycoside hydrolases”. Biochem. J. 394: 675—686. PMID 16316314.
^ Ike, M., Isami, K., Tanabe, Y., Nogawa, M., Ogasawara, W., Okada, H. and Morikawa, Y. (2006). „Cloning and heterologous expression of the exo-β-D-glucosaminidase-encoding gene (gls93) from a filamentous fungus, Trichoderma reesei PC-3-7”. Appl. Microbiol. Biotechnol. 72: 687—695. PMID 16636831.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Exo-1,4-beta-D-glucosaminidase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Nanjo, F., Katsumi, R. and Sakai, K. (1990). „Purification and characterization of an exo-β-D-glucosaminidase, a novel type of enzyme, from Nocardia orientalis”. J. Biol. Chem. 265: 10088—10094. PMID 2351651.

[2] Nogawa, M., Takahashi, H., Kashiwagi, A., Ohshima, K., Okada, H. and Morikawa, Y. (1998). „Purification and characterization of exo-β-D-glucosaminidase from a cellulolytic fungus, Trichoderma reesei PC-3-7”. Appl. Environ. Microbiol. 64: 890—895. PMID 16349528.

[3] Fukamizo, T., Fleury, A., Côté, N., Mitsutomi, M. and Brzezinski, R. (2006). „Exo-β-D-glucosaminidase from Amycolatopsis orientalis: catalytic residues, sugar recognition specificity, kinetics, and synergism”. Glycobiology. 16: 1064—1072. PMID 16877749.

[4] Côté, N., Fleury, A., Dumont-Blanchette, E., Fukamizo, T., Mitsutomi, M. and Brzezinski, R. (2006). „Two exo-β-D-glucosaminidases/exochitosanases from actinomycetes define a new subfamily within family 2 of glycoside hydrolases”. Biochem. J. 394: 675—686. PMID 16316314.

[5] Ike, M., Isami, K., Tanabe, Y., Nogawa, M., Ogasawara, W., Okada, H. and Morikawa, Y. (2006). „Cloning and heterologous expression of the exo-β-D-glucosaminidase-encoding gene (gls93) from a filamentous fungus, Trichoderma reesei PC-3-7”. Appl. Microbiol. Biotechnol. 72: 687—695. PMID 16636831.

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