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PubMed	članci
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Ekdizon 20-monooksigenaza
Ekdizon 20-monooksigenaza
Identifikatori
EC broj	1.14.99.22
CAS broj	55071-97-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Ekdizon 20-monooksigenaza (EC 1.14.99.22, alfa-ekdizonska C-20 hidroksilaza, ekdizonska 20-hidroksilaza) je enzim sa sistematskim imenom ekdizon,vodonik-donor:kiseonik oksidoreduktaza (20-hidroksilacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ekdizon + AH₂ + O₂

\rightleftharpoons

20-hidroksiekdizon + A + H₂O

Enzim iz telesne masti insekata je hem-tiolatni protein (P-450). NADPH može da deluje kao donor vodonika.

Reference

^ Johnson, P. & Rees, H.H. (1977). „The mechanism of C-20 hydroxylation of α-ecdysone in the desert locust, Schistocerca gregaria”. Biochem. J. 168: 513—520. PMID 606249.
^ Nigg, H.N., Svoboda, J.A., Thompson, M.J., Dutky, S.R., Kaplanis, J.N. and Robbins, W.E. (1976). „Ecdysome 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.)”. Experientia. 32: 438—439. PMID 5286.
^ Smith, S.L., Bollenbacher, W.E., Cooper, D.Y., Schleyer, H., Wielgus, J.J. and Gilbert, L.I. (1979). „Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase”. Mol. Cell. Endocrinol. 15: 111—133. PMID 488526.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Ecdysone+20-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Johnson, P. & Rees, H.H. (1977). „The mechanism of C-20 hydroxylation of α-ecdysone in the desert locust, Schistocerca gregaria”. Biochem. J. 168: 513—520. PMID 606249.

[2] Nigg, H.N., Svoboda, J.A., Thompson, M.J., Dutky, S.R., Kaplanis, J.N. and Robbins, W.E. (1976). „Ecdysome 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.)”. Experientia. 32: 438—439. PMID 5286.

[3] Smith, S.L., Bollenbacher, W.E., Cooper, D.Y., Schleyer, H., Wielgus, J.J. and Gilbert, L.I. (1979). „Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase”. Mol. Cell. Endocrinol. 15: 111—133. PMID 488526.

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