PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Dolihil-P-Man:Man8GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza
Dolihil-P-Man:Man8GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza
Identifikatori
EC broj	2.4.1.261
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Dolihil-P-Man:Man8GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza (EC 2.4.1.261, ALG9, ALG9 alfa1,2 manoziltransferaza, dolihilfosfomanoza-zavisna ALG9 manoziltransferaza, ALG9 manoziltransferaza, Dol-P-Man:Man8GlcNAc2-PP-Dol alfa-1,2-manoziltransferaza) je enzim sa sistematskim imenom dolihil beta-D-manozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->6))-D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol 2-alfa-D-manoziltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

dolihil beta-D-manozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol

\rightleftharpoons

D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + dolihil fosfat

Tokom formiranja N-glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih oligosaharida sa Glc3Man9GlcNAc2 osnovom na lipidnom nosiocu dolihil difosfatu.

Reference

^ Vleugels, W., Keldermans, L., Jaeken, J., Butters, T.D., Michalski, J.C., Matthijs, G. and Foulquier, F. (2009). „Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient”. Glycobiology. 19: 910—917. PMID 19451548.
^ Frank, C.G. & Aebi, M. (2005). „ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis”. Glycobiology. 15: 1156—1163. PMID 15987956.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol+alpha-1,2-mannosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Vleugels, W., Keldermans, L., Jaeken, J., Butters, T.D., Michalski, J.C., Matthijs, G. and Foulquier, F. (2009). „Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient”. Glycobiology. 19: 910—917. PMID 19451548.

[2] Frank, C.G. & Aebi, M. (2005). „ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis”. Glycobiology. 15: 1156—1163. PMID 15987956.

[1]

[2]