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Dolihil-P-Man:Man5GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza
Dolihil-P-Man:Man5GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza
Identifikatori
EC broj	2.4.1.258
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Dolihil-P-Man:Man5GlcNAc2-PP-dolihol alfa-1,3-manoziltransferaza (EC 2.4.1.258, Man5GlcNAc2-PP-Dol manoziltransferaza, ALG3, dolihil-P-Man:Man(5)GlcNAc(2)-PP-dolihil manoziltransferaza, Not56-slični protein, Alg3 alfa-1,3-manozil transferaza, Dol-P-Man:Man5GlcNAc2-PP-Dol alfa-1,3-manoziltransferaza) je enzim sa sistematskim imenom dolihil beta-D-manozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-1,3-manoziltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

dolihil beta-D-manozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol

\rightleftharpoons

D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + dolihil fosfat

Tokom formiranja N-glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih oligosaharida sa Glc3Man9GlcNAc2 osnovom na lipidnom nosiocu dolihil difosfatu.

Reference

^ Sharma, C.B., Knauer, R. and Lehle, L. (2001). „Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man₅GlcNAc₂-PP-Dol mannosyltransferase”. Biol. Chem. 382: 321—328. PMID 11308030.
^ Cipollo, J.F. & Trimble, R.B. (2000). „The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Δalg9 mutant reveals a regulatory role for the Alg3p α1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing”. J. Biol. Chem. 275: 4267—4277. PMID 10660594.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol+alpha-1,3-mannosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Sharma, C.B., Knauer, R. and Lehle, L. (2001). „Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man₅GlcNAc₂-PP-Dol mannosyltransferase”. Biol. Chem. 382: 321—328. PMID 11308030.

[2] Cipollo, J.F. & Trimble, R.B. (2000). „The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Δalg9 mutant reveals a regulatory role for the Alg3p α1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing”. J. Biol. Chem. 275: 4267—4277. PMID 10660594.

[1]

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