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Dimetilmalat dehidrogenaza
Dimetilmalat dehidrogenaza
Identifikatori
EC broj	1.1.1.84
CAS broj	37250-21-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Dimetilmalat dehidrogenaza (EC 1.1.1.84, beta,beta-dimetilmalatna dehidrogenaza) je enzim sa sistematskim imenom (R)-3,3-dimetilmalat:NAD⁺ oksidoreduktaza (dekarboksilacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(R)-3,3-dimetilmalat + NAD⁺

\rightleftharpoons

3-metil-2-oksobutanoat + CO₂ + NADH

Dimetilmalatnoj dehidrogenazi je neophodan K⁺ ili NH₄⁺ i Mn²⁺ ili Co²⁺. Ona takođe deluje on (R)-malat.

Reference

^ Magee, P.T. & Snell, E.E. (1966). „The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to α-ketoisovalerate”. Biochemistry. 5: 409—416. PMID 4287371.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Dimethylmalate+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Magee, P.T. & Snell, E.E. (1966). „The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to α-ketoisovalerate”. Biochemistry. 5: 409—416. PMID 4287371.

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