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Digalaktozildiacilglicerol sintaza
Digalaktozildiacilglicerol sintaza
Identifikatori
EC broj	2.4.1.241
CAS broj	69913-00-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Digalaktozildiacilglicerol sintaza (EC 2.4.1.241, DGD1, DGD2, DGDG sintaza, UDP-galaktoza-zavisna DGDG sintaza, UDP-galaktoza-zavisna digalaktozildiacilglicerol sintaza, UDP-galaktoza:MGDG galaktoziltransferaza, UDP-galaktoza:3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol 6-alfa-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol 6-alfa-galaktoziltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-galaktoza + 3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol

\rightleftharpoons

UDP + 3-[alfa-D-galaktozil-(1->6)-beta-D-galaktozil]-1,2-diacil-sn-glicerol

Za dejstvo ovog enzima je neophodan Mg²⁺. Diacilglicerol ne može da služi kao akceptorski molekule za galaktozilaciju u reakciji katalizovanoj enzimom EC 2.4.1.46, monogalaktozildiacilglicerol sintaza.

Reference

^ Kelly, A.A. & Dörmann, P. (2002). „DGD2, an Arabidopsis gene encoding a UDP-galactose-dependent digalactosyldiacylglycerol synthase is expressed during growth under phosphate-limiting conditions”. J. Biol. Chem. 277: 1166—1173. PMID 11696551.
^ Härtel, H., Dörmann, P. and Benning, C. (2000). „DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis”. Proc. Natl. Acad. Sci. USA. 97: 10649—10654. PMID 10973486.
^ Kelly, A.A., Froehlich, J.E. and Dörmann, P. (2003). „Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis”. Plant Cell. 15: 2694—2706. PMID 14600212.
^ Benning, C. & Ohta, H. (2005). „Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants”. J. Biol. Chem. 280: 2397—2400. PMID 15590685.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Digalactosyldiacylglycerol+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kelly, A.A. & Dörmann, P. (2002). „DGD2, an Arabidopsis gene encoding a UDP-galactose-dependent digalactosyldiacylglycerol synthase is expressed during growth under phosphate-limiting conditions”. J. Biol. Chem. 277: 1166—1173. PMID 11696551.

[2] Härtel, H., Dörmann, P. and Benning, C. (2000). „DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis”. Proc. Natl. Acad. Sci. USA. 97: 10649—10654. PMID 10973486.

[3] Kelly, A.A., Froehlich, J.E. and Dörmann, P. (2003). „Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis”. Plant Cell. 15: 2694—2706. PMID 14600212.

[4] Benning, C. & Ohta, H. (2005). „Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants”. J. Biol. Chem. 280: 2397—2400. PMID 15590685.

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