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D-sedoheptuloza 7-fosfatna izomeraza
D-sedoheptuloza 7-fosfatna izomeraza
Identifikatori
EC broj	5.3.1.28
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

D-sedoheptuloza 7-fosfatna izomeraza (EC 5.3.1.28, sedoheptuloza-7-fosfat izomeraza, fosfoheptoza izomeraza, gmhA (gen), lpcA (gen)) je enzim sa sistematskim imenom D-glicero-D-mano-heptoza 7-fosfat aldoza-ketoza-izomeraza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-sedoheptuloza 7-fosfat

\rightleftharpoons

D-glicero-D-mano-heptoza 7-fosfat

Kod Gram-negativih bakterija ovaj enzim učestvuje u biosintezi ADP-L-glicero-beta-D-mano-heptoze.

Reference

^ Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. (2002). „Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli”. J. Bacteriol. 184: 363—369. PMID 11751812.
^ Kneidinger, B., Graninger, M., Puchberger, M., Kosma, P. and Messner, P. (2001). „Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose”. J. Biol. Chem. 276: 20935—20944. PMID 11279237.
^ Valvano, M.A., Messner, P. and Kosma, P. (2002). „Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides”. Microbiology. 148: 1979—1989. PMID 12101286.
^ Kim, M.S. & Shin, D.H. (2009). „A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 1110—1112. PMID 19923728.
^ Taylor, P.L., Blakely, K.M., de Leon, G.P., Walker, J.R., McArthur, F., Evdokimova, E., Zhang, K., Valvano, M.A., Wright, G.D. and Junop, M.S. (2008). „Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants”. J. Biol. Chem. 283: 2835—2845. PMID 18056714.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

D-sedoheptulose+7-phosphate+isomerase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. (2002). „Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli”. J. Bacteriol. 184: 363—369. PMID 11751812.

[2] Kneidinger, B., Graninger, M., Puchberger, M., Kosma, P. and Messner, P. (2001). „Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose”. J. Biol. Chem. 276: 20935—20944. PMID 11279237.

[3] Valvano, M.A., Messner, P. and Kosma, P. (2002). „Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides”. Microbiology. 148: 1979—1989. PMID 12101286.

[4] Kim, M.S. & Shin, D.H. (2009). „A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 1110—1112. PMID 19923728.

[5] Taylor, P.L., Blakely, K.M., de Leon, G.P., Walker, J.R., McArthur, F., Evdokimova, E., Zhang, K., Valvano, M.A., Wright, G.D. and Junop, M.S. (2008). „Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants”. J. Biol. Chem. 283: 2835—2845. PMID 18056714.

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