D-glicero-beta-D-mano-heptoza-7-fosfat kinaza

D-glicero-beta-D-mano-heptoza-7-fosfat kinaza
Identifikatori
EC broj2.7.1.167
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

D-glicero-beta-D-mano-heptoza-7-fosfat kinaza (EC 2.7.1.167, heptoza 7-fosfatna kinaza, D-beta-D-heptozna 7-fosfotransferaza, D-beta-D-heptoza-7-fosfatna kinaza, HldE1 heptokinaza, glicero-mano-heptozna 7-fosfat kinaza, D-beta-D-heptoza 7-fosfatna kinaza/D-beta-D-heptoza 1-fosfat adenililtransferaza, hldE (gen), rfaE (gen)) je enzim sa sistematskim imenom ATP:D-glicero-beta-D-mano-heptoza 7-fosfat 1-fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-glicero-beta-D-mano-heptoza 7-fosfat + ATP D-glicero-beta-D-mano-heptoza 1,7-bisfosfat + ADP

Ovaj bifunkcionalani protein hldE deluje kao D-glicero-beta-D-mano-heptoza-7-fosfatna kinaza i D-glicero-beta-D-mano-heptoza 1-fosfat adenililtransferaza (cf. EC 2.7.7.70).

Reference

  1. ^ McArthur, F., Andersson, C.E., Loutet, S., Mowbray, S.L. and Valvano, M.A. (2005). „Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis”. J. Bacteriol. 187: 5292—5300. PMID 16030223. 
  2. ^ Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. (2002). „Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli”. J. Bacteriol. 184: 363—369. PMID 11751812. 
  3. ^ Valvano, M.A., Messner, P. and Kosma, P. (2002). „Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides”. Microbiology. 148: 1979—1989. PMID 12101286. 
  4. ^ Jin, U.H., Chung, T.W., Lee, Y.C., Ha, S.D. and Kim, C.H. (2001). „Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium”. Glycoconj. J. 18: 779—787. PMID 12441667. 
  5. ^ Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. (2010). „Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)”. Biochemistry. 49: 1072—1081. PMID 20050615. 

Literatura

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