Cefotiam

Cefotiam
IUPAC ime
(6R,7R)-7-[2-(2-amino-1,3-tiazol-4-il)acetamido]-3-[({1-[2-(dimetilamino)etil]-1H-1,2,3,4-tetrazol-5-il}sulfanil)metil]-8-okso-5-tia-1-azabiciklo[4.2.0]okt-2-en-2-karboksilna kiselina
Klinički podaci
Drugs.comMonografija
Farmakokinetički podaci
Poluvreme eliminacije1 sat
Identifikatori
CAS broj61622-34-2 ДаY
ATC kodJ01DC07 (WHO)
PubChemCID 43708
DrugBankDB00229 ДаY
ChemSpider39831 ДаY
ChEMBLCHEMBL355510 ДаY
Hemijski podaci
FormulaC18H23N9O4S3
Molarna masa525.628
  • [H][C@]12SCC(CSC3=NN=NN3CCN(C)C)=C(N1C(=O)[C@H]2NC(=O)CC1=CSC(N)=N1)C(O)=O
  • InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 ДаY
  • Key:QYQDKDWGWDOFFU-IUODEOHRSA-N ДаY

Cevalotiam' je jedan od cefalosporina, koji ima širok spektar dejstva proti gram-pozitivnih i gram-negativnih mikroorganizama.[1][2][3][4][5]

Reference

  1. ^ Muller R, Bottger C, Wichmann G: Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients. Arzneimittelforschung. 2003;53(2):126-32. PMID 12642969
  2. ^ Kolben M, Mandoki E, Ulm K, Freitag K: Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section. Eur J Clin Microbiol Infect Dis. 2001 Jan;20(1):40-2. PMID 11245321
  3. ^ Shimizu S, Chen KR, Miyakawa S: Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses. Dermatology. 1996;192(2):174-6. PMID 8829507
  4. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682. 
  5. ^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412. 

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