PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Brahiurin
Brahiurin
Identifikatori
EC broj	3.4.21.32
CAS broj	848900-32-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Brahiurin (EC 3.4.21.32, proteaza I raka, proteaza II raka) je enzim.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina sa širokom specifičnošću za peptidne veze. Prirodni kolagen se razlaže na oko 75% dužine molekula sa N-terminusa. Niska aktivnost na malim molekulskim supstratima tripsina i himotripsina

Ovaj enzim je izolovan iz raka, Uca pugilator.

Reference

^ Hurion, N., Fromentin, H. and Keil, B. (1979). „Specificity of the collagenolytic enzyme from the fungus Entomophthora coronata: comparison with the bacterial collagenase from Achromobacter iophagus”. Arch. Biochem. Biophys. 192: 438—445. PMID 219780.
^ Grant, G.A., Eisen, A.Z. and Bradshaw, R.A. (1981). „Collagenolytic protease from fiddler crab (Uca pugilator)”. Methods Enzymol. 80: 722—734.
^ Welgus, H.G., Grant, G.A., Jeffrey, J.J. and Eisen, A.Z. (1982). „Substrate specificity of the collagenolytic serine protease from Uca pugilator: studies with collagenous substrates”. Biochemistry. 21: 5183—5189. PMID 6756469.
^ Welgus, H.G. & Grant, G.A. (1983). „Degradation of collagen substrates by a trypsin-like serine protease form the fiddler crab Uca pugilator”. Biochemistry. 22: 2228—2233. PMID 6305411.
^ Klimova, O.A., Borukhov, S.I., Solovyeva, N.I., Balaevskaya, T.O. and Strongin, A.Y. (1990). „The isolation and properties of collagenolytic proteases from crab hepatopancreas”. Biochem. Biophys. Res. Commun. 166: 1411—1420. PMID 2154979.
^ Lu, P.-J., Liu, H.-C. and Tsai, I.-H. (1990). „The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens”. Biol. Chem. Hoppe-Seyler. 371: 851—859. PMID 1963309.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Brachyurin на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hurion, N., Fromentin, H. and Keil, B. (1979). „Specificity of the collagenolytic enzyme from the fungus Entomophthora coronata: comparison with the bacterial collagenase from Achromobacter iophagus”. Arch. Biochem. Biophys. 192: 438—445. PMID 219780.

[2] Grant, G.A., Eisen, A.Z. and Bradshaw, R.A. (1981). „Collagenolytic protease from fiddler crab (Uca pugilator)”. Methods Enzymol. 80: 722—734.

[3] Welgus, H.G., Grant, G.A., Jeffrey, J.J. and Eisen, A.Z. (1982). „Substrate specificity of the collagenolytic serine protease from Uca pugilator: studies with collagenous substrates”. Biochemistry. 21: 5183—5189. PMID 6756469.

[4] Welgus, H.G. & Grant, G.A. (1983). „Degradation of collagen substrates by a trypsin-like serine protease form the fiddler crab Uca pugilator”. Biochemistry. 22: 2228—2233. PMID 6305411.

[5] Klimova, O.A., Borukhov, S.I., Solovyeva, N.I., Balaevskaya, T.O. and Strongin, A.Y. (1990). „The isolation and properties of collagenolytic proteases from crab hepatopancreas”. Biochem. Biophys. Res. Commun. 166: 1411—1420. PMID 2154979.

[6] Lu, P.-J., Liu, H.-C. and Tsai, I.-H. (1990). „The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens”. Biol. Chem. Hoppe-Seyler. 371: 851—859. PMID 1963309.

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