Atrolizin-A

Atrolizin-A
Identifikatori
EC broj3.4.24.1
CAS broj37288-82-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Atrolizin-A (EC 3.4.24.1, Crotalus atrox metaloendopeptidaza a, hemoragijski toksin a, Crotalus atrox alfa-proteinaza, Crotalus atrox proteinaza, botropajin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje Asn3-Gln, His5-Leu, His10-Leu, Ala14-Leu i Tyr16-Leu u insulinskom B lancu. Uklanjanje C-terminalnog Leu sa malih peptida

Ova hemoragijska endopeptidaza je jedna od šest hemoragijskih toksina u venomu zvečarke Crotalus atrox.

Reference

  1. ^ Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790. 
  2. ^ Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). „Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom”. Arch. Biochem. Biophys. 253: 108—121. PMID 2949699. 
  3. ^ Bjarnason, J.B., Hamilton, D. and Fox, J.W. (1988). „Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom”. Biol. Chem. Hoppe-Seyler. 369: 121—129. PMID 3060135. 
  4. ^ Bjarnason, J.B. & Fox, J.W. (1989). „Hemorrhagic toxins from snake venoms”. J. Toxicol. Toxin Rev. 7: 121—209. 

Literatura

Spoljašnje veze

  • Atrolysin+A на US National Library of Medicine Medical Subject Headings (MeSH)