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Alifatična aldoksimna dehidrataza
Alifatična aldoksimna dehidrataza
Identifikatori
EC broj	4.99.1.5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Alifatična aldoksimna dehidrataza (EC 4.99.1.5, OxdA, alifatična aldoksimska hidrolijaza) je enzim sa sistematskim imenom alifatični aldoksim hidrolijaza (formira alifatični-nitril).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

alifatični aldoksim

\rightleftharpoons

alifatični nitril + H₂O

Enzim iz Pseudomonas hlororaphis sadrži Ca²⁺ i protohem IX.

Reference

^ Oinuma, K.-I., Hashimoto, Y., Konishi, K., Goda, M., Noguchi, T., Higashibata, H. and Kobayashi, M. (2003). „Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23: Sequencing, gene expression, purification and characterization”. J. Biol. Chem. 278: 29600—29608. PMID 12773527.
^ Xie, S.X., Kato, Y., Komeda, H., Yoshida, S. and Asano, Y. (2003). „A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4”. Biochemistry. 42: 12056—12066. PMID 14556637.
^ Kato, Y., Yoshida, S., Xie, S.-X. and Asano, Y. (2004). „Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771”. J. Biosci. Bioeng. 97: 250—259. PMID 16233624.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Aliphatic+aldoxime+dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Oinuma, K.-I., Hashimoto, Y., Konishi, K., Goda, M., Noguchi, T., Higashibata, H. and Kobayashi, M. (2003). „Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23: Sequencing, gene expression, purification and characterization”. J. Biol. Chem. 278: 29600—29608. PMID 12773527.

[2] Xie, S.X., Kato, Y., Komeda, H., Yoshida, S. and Asano, Y. (2003). „A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4”. Biochemistry. 42: 12056—12066. PMID 14556637.

[3] Kato, Y., Yoshida, S., Xie, S.-X. and Asano, Y. (2004). „Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771”. J. Biosci. Bioeng. 97: 250—259. PMID 16233624.

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