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PMC	članci
PubMed	članci
NCBI	proteini

Acetoacetil-KoA sintaza
Acetoacetil-KoA sintaza
Identifikatori
EC broj	2.3.1.194
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Acetoacetil-KoA sintaza (EC 2.3.1.194, NphT7) je enzim sa sistematskim imenom acetil-KoA:malonil-KoA C-acetiltransferaza (dekarboksilacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + malonil-KoA

\rightleftharpoons

acetoacetil-KoA + KoA + CO₂

Enzim iz zemljišne bakterije Streptomyces sp. CL190 formira acetoacetil-KoA koji se koristi u produkciji mevalonata.

Reference

^ Okamura, E., Tomita, T., Sawa, R., Nishiyama, M. and Kuzuyama, T. (2010). „Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway”. Proc. Natl. Acad. Sci. USA. 107: 11265—11270. PMID 20534558.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Acetoacetyl-CoA+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Okamura, E., Tomita, T., Sawa, R., Nishiyama, M. and Kuzuyama, T. (2010). „Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway”. Proc. Natl. Acad. Sci. USA. 107: 11265—11270. PMID 20534558.

[1]