ADP-ribozilargininska hidrolaza
ADP-ribozilargininska hidrolaza (EC 3.2.2.19, enzim razlaganja ADP-riboza-L-arginina, Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza, protein-omega-N-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza) je enzim sa sistematskim imenom protein-Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) protein-Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + protein-L-arginin
- (2) Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + L-arginin
Ovaj enzim uklanja ADP-ribozu sa argininskih ostataka u ADP-ribozilisanim proteinima.
Reference
- ^ Moss, J., Jacobson, M.K. and Stanley, S.J. (1985). „Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme”. Proc. Natl. Acad. Sci. USA. 82: 5603—5607. PMID 2994036.
- ^ Moss, J., Stanley, S.J., Nightingale, M.S., Murtagh, J.J., Jr., Monaco, L., Mishima, K., Chen, H.C., Williamson, K.C. and Tsai, S.C. (1992). „Molecular and immunological characterization of ADP-ribosylarginine hydrolases”. J. Biol. Chem. 267: 10481—10488. PMID 1375222.
- ^ Konczalik, P. & Moss, J. (1999). „Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases”. J. Biol. Chem. 274: 16736—16740. PMID 10358013.
- ^ Takada, T., Iida, K. and Moss, J. (1993). „Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase”. J. Biol. Chem. 268: 17837—17843. PMID 8349667.
- ^ Ohno, T., Tsuchiya, M., Osago, H., Hara, N., Jidoi, J. and Shimoyama, M. (1995). „Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase”. Anal. Biochem. 10: 115—122. PMID 8678289.
Literatura
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