ADP-ribozilargininska hidrolaza

ADP-ribozilargininska hidrolaza
Identifikatori
EC broj3.2.2.19
CAS broj98668-52-1
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

ADP-ribozilargininska hidrolaza (EC 3.2.2.19, enzim razlaganja ADP-riboza-L-arginina, Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza, protein-omega-N-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza) je enzim sa sistematskim imenom protein-Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) protein-Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + protein-L-arginin
(2) Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + L-arginin

Ovaj enzim uklanja ADP-ribozu sa argininskih ostataka u ADP-ribozilisanim proteinima.

Reference

  1. ^ Moss, J., Jacobson, M.K. and Stanley, S.J. (1985). „Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme”. Proc. Natl. Acad. Sci. USA. 82: 5603—5607. PMID 2994036. 
  2. ^ Moss, J., Stanley, S.J., Nightingale, M.S., Murtagh, J.J., Jr., Monaco, L., Mishima, K., Chen, H.C., Williamson, K.C. and Tsai, S.C. (1992). „Molecular and immunological characterization of ADP-ribosylarginine hydrolases”. J. Biol. Chem. 267: 10481—10488. PMID 1375222. 
  3. ^ Konczalik, P. & Moss, J. (1999). „Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases”. J. Biol. Chem. 274: 16736—16740. PMID 10358013. 
  4. ^ Takada, T., Iida, K. and Moss, J. (1993). „Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase”. J. Biol. Chem. 268: 17837—17843. PMID 8349667. 
  5. ^ Ohno, T., Tsuchiya, M., Osago, H., Hara, N., Jidoi, J. and Shimoyama, M. (1995). „Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase”. Anal. Biochem. 10: 115—122. PMID 8678289. 

Literatura

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