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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

9,12-Oktadekadienoat 8-hidroperoksidna 8R-izomeraza
9,12-Oktadekadienoat 8-hidroperoksidna 8R-izomeraza
Identifikatori
EC broj	5.4.4.5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

9,12-Oktadekadienoat 8-hidroperoksidna 8R-izomeraza (EC 5.4.4.5, 5,8-LDS (bifunkcionalan enzim), 5,8-linoleat diolna sintaza (bifunkcionalani enzim), 8-hidroperoksidna izomeraza, (8R,9Z,12Z)-8-hidroperoksi-9,12-octadekadienoatna mutaza (formira (5S,8R,9Z,12Z)-5,8-dihidroksi-9,12-oktadekadienoat), PpoA) je enzim sa sistematskim imenom (8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat hidroksimutaza (formira (5S,8R,9Z,12Z)-5,8-dihidroksioktadeka-9,12-dienoat).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(8R,9Z,12Z)-8-hidroperoksioktadeka-9,12-dienoat

\rightleftharpoons

(5S,8R,9Z,12Z)-5,8-dihidroksioktadeka-9,12-dienoat

Ovaj enzim sadrži hem.

Reference

^ Hoffmann, I., Jerneren, F., Garscha, U. and Oliw, E.H. (2011). „Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase”. Arch. Biochem. Biophys. 506: 216—222. PMID 21130068.
^ Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta. 1801: 503—507. PMID 20045744.
^ Brodhun, F., Gobel, C., Hornung, E. and Feussner, I. (2009). „Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P₄₅₀”. J. Biol. Chem. 284: 11792—11805. PMID 19286665.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

9,12-octadecadienoate+8-hydroperoxide+8R-isomerase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hoffmann, I., Jerneren, F., Garscha, U. and Oliw, E.H. (2011). „Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase”. Arch. Biochem. Biophys. 506: 216—222. PMID 21130068.

[2] Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta. 1801: 503—507. PMID 20045744.

[3] Brodhun, F., Gobel, C., Hornung, E. and Feussner, I. (2009). „Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P₄₅₀”. J. Biol. Chem. 284: 11792—11805. PMID 19286665.

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