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6-Fosfo-3-heksuloizomeraza
6-Fosfo-3-heksuloizomeraza
Identifikatori
EC broj	5.3.1.27
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

6-Fosfo-3-heksuloizomeraza (EC 5.3.1.27, 3-heksuloza-6-fosfat izomeraza, fosfo-3-heksuloizomeraza, PHI, 6-fosfo-3-heksuloza izomeraza, YckF) je enzim sa sistematskim imenom D-arabino-heks-3-uloza-6-fosfat izomeraza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-arabino-heks-3-uloza 6-fosfat

\rightleftharpoons

D-fruktoza 6-fosfat

Ovaj enzim učestvuje u ribuloza-monofosfatnom ciklusu formaldehidne fiksacije.

Reference

^ Ferenci, T., Strøm, T. and Quayle, J.R. (1974). „Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus”. Biochem. J. 144: 477—486. PMID 4219834.
^ Yurimoto, H., Kato, N. and Sakai, Y. (2005). „Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism”. Chem. Rec. 5: 367—375. PMID 16278835.
^ Kato, N., Yurimoto, H. and Thauer, R.K. (2006). „The physiological role of the ribulose monophosphate pathway in bacteria and archaea”. Biosci. Biotechnol. Biochem. 70: 10—21. PMID 16428816.
^ Orita, I., Yurimoto, H., Hirai, R., Kawarabayasi, Y., Sakai, Y. and Kato, N. (2005). „The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway”. J. Bacteriol. 187: 3636—3642. PMID 15901685.
^ Martinez-Cruz, L.A., Dreyer, M.K., Boisvert, D.C., Yokota, H., Martinez-Chantar, M.L., Kim, R. and Kim, S.H. (2002). „Crystal structure of MJ1247 protein from M. jannaschii at 2.0 Å resolution infers a molecular function of 3-hexulose-6-phosphate isomerase”. Structure. 10: 195—204. PMID 11839305.
^ Taylor, E.J., Charnock, S.J., Colby, J., Davies, G.J. and Black, G.W. (2001). „Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis”. Acta Crystallogr. D Biol. Crystallogr. 57: 1138—1140. PMID 11468398.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

6-phospho-3-hexuloisomerase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Ferenci, T., Strøm, T. and Quayle, J.R. (1974). „Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus”. Biochem. J. 144: 477—486. PMID 4219834.

[2] Yurimoto, H., Kato, N. and Sakai, Y. (2005). „Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism”. Chem. Rec. 5: 367—375. PMID 16278835.

[3] Kato, N., Yurimoto, H. and Thauer, R.K. (2006). „The physiological role of the ribulose monophosphate pathway in bacteria and archaea”. Biosci. Biotechnol. Biochem. 70: 10—21. PMID 16428816.

[4] Orita, I., Yurimoto, H., Hirai, R., Kawarabayasi, Y., Sakai, Y. and Kato, N. (2005). „The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway”. J. Bacteriol. 187: 3636—3642. PMID 15901685.

[5] Martinez-Cruz, L.A., Dreyer, M.K., Boisvert, D.C., Yokota, H., Martinez-Chantar, M.L., Kim, R. and Kim, S.H. (2002). „Crystal structure of MJ1247 protein from M. jannaschii at 2.0 Å resolution infers a molecular function of 3-hexulose-6-phosphate isomerase”. Structure. 10: 195—204. PMID 11839305.

[6] Taylor, E.J., Charnock, S.J., Colby, J., Davies, G.J. and Black, G.W. (2001). „Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis”. Acta Crystallogr. D Biol. Crystallogr. 57: 1138—1140. PMID 11468398.

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