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4-hidroksitreonin-4-fosfat dehidrogenaza
4-hidroksitreonin-4-fosfat dehidrogenaza
Identifikatori
EC broj	1.1.1.262
CAS broj	230310-36-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

4-hidroksitreonin-4-fosfat dehidrogenaza (EC 1.1.1.262, NAD⁺-zavisni treonin 4-fosfat dehidrogenaza, L-treonin 4-fosfat dehidrogenaza, 4-(fosfohidroksi)-L-treonin dehidrogenaza, PdxA, 4-(fosfonooksi)-L-treonin:NAD⁺ oksidoreduktaza) je enzim sa sistematskim imenom 4-fosfonooksi-L-treonin:NAD⁺ oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

4-fosfonooksi-L-treonin + NAD⁺

\rightleftharpoons

3-amino-2-oksopropil fosfat + CO₂ + NADH + H⁺ (sveukupna reakcija)

(1a) 4-fosfonooksi-L-treonin + NAD⁺

\rightleftharpoons

(2S)-2-amino-3-okso-4-fosfonooksibutanoat + NADH + H⁺

(1b) (2S)-2-amino-3-okso-4-fosfonooksibutanoat

\rightleftharpoons

3-amino-2-oksopropil fosfat + CO₂ (spontana reakcija)

Product reakcije podleže dekarboksilaciji, čime se formira 3-amino-2-oksopropil fosfat. Ovaj enzim je deo biosinetičkog puta koenzima piridoksal 5'-fosfat prusutnog kod anaerobnih bakterija.

Reference

^ Cane, D.E., Hsiung, Y., Cornish, J.A., Robinson, J.K and Spenser, I.D. (1998). „Biosynthesis of vitamine B₆: The oxidation of L-threonine 4-phosphate by PdxA”. J. Am. Chem. Soc. 120: 1936—1937.
^ Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B₆ biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45—48. PMID 10225425.
^ Sivaraman, J., Li, Y., Banks, J., Cane, D.E., Matte, A. and Cygler, M. (2003). „Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway”. J. Biol. Chem. 278: 43682—43690. PMID 12896974.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

4-hydroxythreonine-4-phosphate+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Cane, D.E., Hsiung, Y., Cornish, J.A., Robinson, J.K and Spenser, I.D. (1998). „Biosynthesis of vitamine B₆: The oxidation of L-threonine 4-phosphate by PdxA”. J. Am. Chem. Soc. 120: 1936—1937.

[2] Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. (1999). „Vitamin B₆ biosynthesis: formation of pyridoxine 5′-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein”. FEBS Lett. 449: 45—48. PMID 10225425.

[3] Sivaraman, J., Li, Y., Banks, J., Cane, D.E., Matte, A. and Cygler, M. (2003). „Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway”. J. Biol. Chem. 278: 43682—43690. PMID 12896974.

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