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3-Fenilpropionat dioksigenaza
3-Fenilpropionat dioksigenaza
Identifikatori
EC broj	1.14.12.19
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

3-Fenilpropionat dioksigenaza (EC 1.14.12.19, HcaA1A2CD, Hca dioksigenaza, 3-fenilpropionatna dioksigenaza) je enzim sa sistematskim imenom 3-fenilpropanoat,NADH:kiseonik oksidoreduktaza (2,3-hidroksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) 3-fenilpropanoat + NADH + H⁺ + O₂

\rightleftharpoons

3-(cis-5,6-dihidroksicikloheksa-1,3-dien-1-il)propanoat + NAD⁺

(2) (2E)-3-fenilprop-2-enoat + NADH + H⁺ + O₂

\rightleftharpoons

(2E)-3-(2,3-dihidroksifenil)prop-2-enoat + NAD⁺

Ovaj enzim učestvuje u degradaciji fenilpropanoidnih jedinjenja. On katalizuje umetanje oba atoma molekulskog kiseonika u pozicije 2 i 3 fenilnog prstena 3-fenilpropanoat ili (2E)-3-fenilprop-2-enoata.

Reference

^ Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915—2923. PMID 9603882.
^ Burlingame, R. & Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113—121. PMID 6345502.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

3-phenylpropanoate+dioxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915—2923. PMID 9603882.

[2] Burlingame, R. & Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113—121. PMID 6345502.

[1]

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