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2-oksopropil-KoM reduktaza (karboksilacija)
2-oksopropil-KoM reduktaza (karboksilacija)
Identifikatori
EC broj	1.8.1.5
CAS broj	244301-63-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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2-oksopropil-KoM reduktaza (karboksilacija) (EC 1.8.1.5, NADPH:2-(2-ketopropiltio)etansulfonat oksidoreduktaza/karboksilaza, NADPH:2-ketopropil-koenzim M oksidoreduktaza/karboksilaza) je enzim sa sistematskim imenom 2-merkaptoetansulfonat,acetoacetat:NADP⁺ oksidoreduktaza (dekarboksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2-merkaptoetansulfonat + acetoacetat + NADP⁺

\rightleftharpoons

2-(2-oksopropiltio)etansulfonat + CO₂ + NADPH

Ovaj enzim takođe deluje na tioetre.

Reference

^ Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. (1999). „A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation”. Proc. Natl. Acad. Sci. USA. 96: 8432—8437. PMID 10411892.
^ Clark, D.D., Allen, J.R. and Ensign, S.A. (2000). „Characterization of five catalytic activities associated with the NADPH:2-ketopropyl-coenzyme M [2-(2-ketopropylthio)ethanesulfonate] oxidoreductase/carboxylase of the Xanthobacter strain Py2 epoxide carboxylase system”. Biochemistry. 39: 1294—1304. PMID 10684609.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

2-oxopropyl-CoM+reductase+(carboxylating) на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. (1999). „A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation”. Proc. Natl. Acad. Sci. USA. 96: 8432—8437. PMID 10411892.

[2] Clark, D.D., Allen, J.R. and Ensign, S.A. (2000). „Characterization of five catalytic activities associated with the NADPH:2-ketopropyl-coenzyme M [2-(2-ketopropylthio)ethanesulfonate] oxidoreductase/carboxylase of the Xanthobacter strain Py2 epoxide carboxylase system”. Biochemistry. 39: 1294—1304. PMID 10684609.

[1]

[2]