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PubMed	članci
NCBI	proteini

2-Dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisni)
2-Dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisni)
Identifikatori
EC broj	1.1.99.38
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

2-Dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisni) (EC 1.1.99.38, btrN (gen)) je enzim sa sistematskim imenom 2-dezoksi-scilo-inozamin:S-adenosyl-L-metionin 1-oksidoreduktaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2-dezoksi-scilo-inozamin + S-adenozil-L-metionin

\rightleftharpoons

3-amino-2,3-didezoksi-scilo-inosoza + 5'-dezoksiadenozin + L-metionin

Ovaj enzim učestvuje u biosintezi aminoglikozidnih antibiotika iz butirozinske familije. Enzim iz Bacillus circulans koristi S-adenozil-L-metionin (SAM), cf. EC 1.1.1.329, 2-dezoksi-scilo-inozamin dehidrogenaza.

Reference

^ Yokoyama, K., Numakura, M., Kudo, F., Ohmori, D. and Eguchi, T. (2007). „Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin”. J. Am. Chem. Soc. 129: 15147—15155. PMID 18001019.
^ Yokoyama, K., Ohmori, D., Kudo, F. and Eguchi, T. (2008). „Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy”. Biochemistry. 47: 8950—8960. PMID 18672902.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

2-deoxy-scyllo-inosamine+dehydrogenase+(SAM-dependent) на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Yokoyama, K., Numakura, M., Kudo, F., Ohmori, D. and Eguchi, T. (2007). „Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin”. J. Am. Chem. Soc. 129: 15147—15155. PMID 18001019.

[2] Yokoyama, K., Ohmori, D., Kudo, F. and Eguchi, T. (2008). „Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy”. Biochemistry. 47: 8950—8960. PMID 18672902.

[1]

[2]