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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

2',3'-Ciklični-nukleotid 3'-fosfodiestaraza
2',3'-Ciklični-nukleotid 3'-fosfodiestaraza
Identifikatori
EC broj	3.1.4.37
CAS broj	60098-35-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

2',3'-Ciklični-nukleotid 3'-fosfodiestaraza (EC 3.1.4.37, ciklična-CMP fosfodiesteraza, 2',3'-ciklična AMP fosfodiesteraza, ciklična 2',3'-nukleotidna 3'-fosfodiesteraza, ciklična 2',3'-nukleotidna fosfodiesteraza, 2',3'-ciklična nukleozid monofosfatna fosfodiesteraza, 2',3'-ciklična nukleotidna 3'-fosfohidrolaza, CNPaza, 2',3'-ciklična nukleotidna fosfohidrolaza, 2':3'-ciklična nukleotidna 3'-fosfodiesteraza, 2':3'-CNMP-3'-aza) je enzim sa sistematskim imenom nukleozid-2',3'-ciklična-fosfat 2'-nukleotidohidrolaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

nukleozid 2',3'-ciklična fosfat + H₂O

\rightleftharpoons

nukleozid 2'-fosfat

Moždani enzim deluje na 2',3'-ciklična AMP brže nego na UMP ili CMP derivate.

Reference

^ Drummond, G.I., Iyer, N.T. and Keith, J. (1962). „Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain”. J. Biol. Chem. 237: 3535—3539.
^ Helfman, D.M. & Kuo, J.F. (1982). „A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2′:3′- and 3′:5′-nucleotides”. J. Biol. Chem. 257: 1044—1047. PMID 6274851.
^ Helfman, D.M., Shoji, M. and Kuo, J.F. (1981). „Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP”. J. Biol. Chem. 256: 6327—6334. PMID 6263914.
^ Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S. (1981). „Chemical, immunological and catalytic properties of 2′:3′-cyclic nucleotide 3′-phosphodiesterase purified from brain white matter”. Biochem. J. 195: 153—157. PMID 6272743.
^ Nishizawa, Y., Kurihara, T. and Takahashi, Y. (1980). „Spectrophotometric assay, solubilization and purification of brain 2′:3′-cyclic nucleotide 3′-phosphodiesterase”. Biochem. J. 191: 71—82. PMID 6258586.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

2',3'-cyclic-nucleotide+3'-phosphodiesterase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Drummond, G.I., Iyer, N.T. and Keith, J. (1962). „Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain”. J. Biol. Chem. 237: 3535—3539.

[2] Helfman, D.M. & Kuo, J.F. (1982). „A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2′:3′- and 3′:5′-nucleotides”. J. Biol. Chem. 257: 1044—1047. PMID 6274851.

[3] Helfman, D.M., Shoji, M. and Kuo, J.F. (1981). „Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP”. J. Biol. Chem. 256: 6327—6334. PMID 6263914.

[4] Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S. (1981). „Chemical, immunological and catalytic properties of 2′:3′-cyclic nucleotide 3′-phosphodiesterase purified from brain white matter”. Biochem. J. 195: 153—157. PMID 6272743.

[5] Nishizawa, Y., Kurihara, T. and Takahashi, Y. (1980). „Spectrophotometric assay, solubilization and purification of brain 2′:3′-cyclic nucleotide 3′-phosphodiesterase”. Biochem. J. 191: 71—82. PMID 6258586.

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