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(R)-6-hidroksinikotin oksidaza
(R)-6-hidroksinikotin oksidaza
Identifikatori
EC broj	1.5.3.6
CAS broj	37233-46-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
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NCBI	proteini

(R)-6-hidroksinikotin oksidaza (EC 1.5.3.6, D-6-hidroksinikotinska oksidaza, 6-hidroksi-D-nikotinska oksidaza) je enzim sa sistematskim imenom (R)-6-hidroksinikotin:kiseonik oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(R)-6-hidroksinikotin + H₂O + O₂

\rightleftharpoons

1-(6-hidroksipiridin-3-il)-4-(metilamino)butan-1-on + H₂O₂

Ovaj enzim je flavoprotein (FAD).

Reference

^ Brühmüller, M., Möhler, H.K. and Decker, K. (1972). „Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase”. Eur. J. Biochem. 29: 143—151. PMID 4628374.
^ Decker, K. & Bleeg, H. (1965). „Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta. 105: 313—324. PMID 5849820.
^ Koetter, J.W. & Schulz, G.E. (2005). „Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans”. J. Mol. Biol. 352: 418—428. PMID 16095622.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

(R)-6-hydroxynicotine+oxidase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Brühmüller, M., Möhler, H.K. and Decker, K. (1972). „Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase”. Eur. J. Biochem. 29: 143—151. PMID 4628374.

[2] Decker, K. & Bleeg, H. (1965). „Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans”. Biochim. Biophys. Acta. 105: 313—324. PMID 5849820.

[3] Koetter, J.W. & Schulz, G.E. (2005). „Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans”. J. Mol. Biol. 352: 418—428. PMID 16095622.

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