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(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza
(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza
Identifikatori
EC broj	2.4.99.13
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
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NCBI	proteini

(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza (EC 2.4.99.13, KDO transferaza, waaA (gen), kdtA (gen), Kdo transferaza, 3-dezoksi-D-mano-okt-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-okt-2-ulozonat:(KDO)-lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

alfa-Kdo-(2->6)-lipid IVA + CMP-alfa-Kdo

\rightleftharpoons

alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP

Ovaj bifunkcionalani enzim iz Escherichia coli prenosi dva 3-dezoksi-D-mano-okt-2-ulozonatna ostataka na lipid IVA (cf. EC 2.4.99.12 [(KDO)-lipid IVA 3-dezoksi-D-mano-oktulozonska kiselina transferaza]).

Reference

^ Belunis, C.J. & Raetz, C.R. (1992). „Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli”. J. Biol. Chem. 267: 9988—9997. PMID 1577828.
^ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391—399. PMID 8748024.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

(KDO)-lipid+IVA+3-deoxy-D-manno-octulosonic+acid+transferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Belunis, C.J. & Raetz, C.R. (1992). „Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli”. J. Biol. Chem. 267: 9988—9997. PMID 1577828.

[2] Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391—399. PMID 8748024.

[1]

[2]