(Acil-nosilac-protein) S-acetiltransferaza

(Acil-nosilac-protein) S-acetiltransferaza
Identifikatori
EC broj2.3.1.38
CAS broj37257-16-2
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

(Acil-nosilac-protein) S-acetiltransferaza (EC 2.3.1.38, acetil koenzim A-acil-nosilac-protein transacilaza, (acil-nosilac-protein)acetiltransferaza, (ACP)acetiltransferaza, ACAT, acetil-KoA:(acil-nosilac-protein) S-acetiltransferaza) je enzim sa sistematskim imenom acetil-KoA:(acil-nosilac protein) S-acetiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + [acil-nosilac protein] KoA + acetil-[acil-nosilac protein]

Ovaj enzim, zajedno sa EC 2.3.1.39, [acil-nosilac-protein] S-maloniltransferazom, je esencijalan za inicijaciju biosinteze masnih kiselina u bakterijama.

Reference

  1. ^ Prescott, D.J. & Vagelos, P.R. (1972). „Acyl carrier protein”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269—311. PMID 4561013. 
  2. ^ Vance, D.E., Mituhashi, O. and Bloch, K. (1973). „Purification and properties of the fatty acid synthetase from Mycobacterium phlei”. J. Biol. Chem. 248: 2303—2309. PMID 4698221. 
  3. ^ Williamson, I.P. & Wakil, S.J. (1966). „Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases”. J. Biol. Chem. 241: 2326—2332. PMID 5330116. 
  4. ^ Lowe, P.N. & Rhodes, S. (1988). „Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli”. Biochem. J. 250: 789—796. PMID 3291856. 
  5. ^ Tsay, J.T., Oh, W., Larson, T.J., Jackowski, S. and Rock, C.O. (1992). „Isolation and characterization of the β-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12”. J. Biol. Chem. 267: 6807—6814. PMID 1551888. 
  6. ^ Rangan, V.S. & Smith, S. (1997). „Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue”. J. Biol. Chem. 272: 11975—11978. PMID 9115261. 

Literatura

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