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(6-4)DNK fotolijaza
(6-4)DNK fotolijaza
Identifikatori
EC broj	4.1.99.13
CAS broj	37290-70-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

(6-4)DNK fotolijaza (EC 4.1.99.13, DNK fotolijaza, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) je enzim sa sistematskim imenom (6-4) fotoprodukt pirimidin-lijaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

(6-4) fotoprodukt (u DNK)

\rightleftharpoons

2 pirimidinski ostaci (u DNK)

Ovaj enzim je flavoprotein (FAD).

Reference

^ Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S. and Getzoff, E.D. (2009). „Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes”. Proc. Natl. Acad. Sci. USA. 106: 6962—6967. PMID 19359474.
^ Schleicher, E., Hitomi, K., Kay, C.W., Getzoff, E.D., Todo, T. and Weber, S. (2007). „Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase”. J. Biol. Chem. 282: 4738—4747. PMID 17164245.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

(6-4)DNA+photolyase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S. and Getzoff, E.D. (2009). „Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes”. Proc. Natl. Acad. Sci. USA. 106: 6962—6967. PMID 19359474.

[2] Schleicher, E., Hitomi, K., Kay, C.W., Getzoff, E.D., Todo, T. and Weber, S. (2007). „Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase”. J. Biol. Chem. 282: 4738—4747. PMID 17164245.

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