Hem O

Hem O
Hem O
Hem O
Všeobecné vlastnosti
Sumárny vzorec C49H58O5N4Fe
Fyzikálne vlastnosti
Molárna hmotnosť 838,854 g/mol
Ďalšie informácie
Číslo CAS 137397-56-9
Pokiaľ je to možné a bežné, používame jednotky sústavy SI.
Ak nie je hore uvedené inak, údaje sú za normálnych podmienok.

Hem O je druh hemu, ktorý je príbuzý hemu A. Na rozdiel od hemu A má však namiesto formylovej skupiny na uhlíku 8 metylovú skupinu.Zároveň je podobný hemu B, ale namiesto vinylovej skupiny na uhlíku 2 má hydroxyfarnezylovú skupinu (ktorá je prítomná i u hemu A).[1]

Funkcia hemu O je podobná hemu A v redukcii kyslíka u cicavcov. Hem O sa nachádza v rôznych bakteriálnych oxidázach,[1] napríklad v terminálnej oxidáze v E. coli.[2][3] Inhibícia syntézy hemu O u Plasmodium falciparum by mohla predstavovať vhodný cieľ antimalarík.[3]

Referencie

  1. a b BOWMAN, Sarah E. J.; BREN, Kara L.. The chemistry and biochemistry of hemec: functional bases for covalent attachment. Natural Product Reports, 2008-11-21, roč. 25, čís. 6, s. 1118–1130. Dostupné online [cit. 2022-08-26]. ISSN 1460-4752. DOI10.1039/B717196J. (po anglicky)
  2. The Nature of the Exchange Coupling between High-Spin Fe(III) Heme o3 and CuB(II) in Escherichia coli Quinol Oxidase, Cytochrome bo3: MCD and EPR Studies. J. Am. Chem. Soc., 2004, s. 4157–4166. DOI10.1021/ja038858m. PMID 15053605.
  3. a b SIMÃO-GURGE, Raquel M.; WUNDERLICH, Gerhard; CRICCO, Julia A.. Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway. Scientific Reports, 2019-12-17, roč. 9, čís. 1, s. 19261. Dostupné online [cit. 2022-08-26]. ISSN 2045-2322. DOI10.1038/s41598-019-55506-y. (po anglicky)

Zdroj

Tento článok je čiastočný alebo úplný preklad článku Heme O na anglickej Wikipédii.

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