John Wayne Mixson (June 16, 1922^[1] – July 8, 2020) was an American politician. He was born in New Brockton, Alabama, but was raised in Jackson County, Florida. He was a democrat.

He served in Florida's House of Representatives. In 1978 he was elected a lieutenant governor (deputy governor) to governor Bob Graham. They were reelected in 1982. Mixson served as lieutenant governor from 1979 to 1987. During his second term he was also state Secretary of Commerce. In 1987, Graham resigned from office to become U.S. Senator. Mixson was sworn in as governor for three days, from January 3 to January 6, when governor-elect Bob Martinez (Rep.) took over.

During the 2004 presidential election, Mixson crossed party lines to endorse the re-election of President George W. Bush.

Mixson died on July 8, 2020 in Tallahassee, Florida at the age of 98.^[2]

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