PROFILPELAJAR.COM

Transcriptome

The transcriptome is the set of all RNA molecules in one cell or a population of cells. RNA transcribes the base sequence from DNA by the process called transcription. The term 'transcriptome' is sometimes used to refer to all RNAs, or just mRNA, depending on the particular experiment.

It includes only those RNA molecules found in a particular cell population. It usually includes the amount or concentration of each RNA molecule, and the molecular identities. It differs from the exome: that refers only to the bits of RNA which do code for proteins.[1]

In the human genome, about 5% of all genes get transcribed into RNA.[2]

The transcriptome is coding mRNA (about 1-4% of its entirety) and non-coding RNAs (the rest). Non-coding RNAs do not give rise to proteins.[3] The number of non-protein-coding sequences increases in more complex organisms.[4]

References

  1. ↑ Wang Z, Gerstein M, Snyder M. 2009. RNA-Seq: a revolutionary tool for transcriptomics. Nature Rev. Genetics 10(1): 57-63.
  2. ↑ C Frith, Martin; Pheasant, Michael; S Mattick, John (2005). "Genomics: The amazing complexity of the human transcriptome". European Journal of Human Genetics. 13 (8): 894–897. doi:10.1038/sj.ejhg.5201459. PMID 15970949. S2CID 2836126.
  3. ↑ Berg JMTJ, Stryer L. 2002. Biochemistry. New York: W H Freeman
  4. ↑ U. Adams, Jill (2008). "Transcriptome: Connecting the genome to gene function". Nature Education. 1 (1): 195.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.