Ryan was seen as a possible presidential candidate in 2020 following the 2018 midterms.[1][2][3] On April 4, 2019, Ryan announced his candidacy for president.[4] On October 24, 2019 Ryan dropped out of the election citing low polling numbers and lack of qualifications for the debates.[5]
In February 2021, Ryan said that he was planning to run for United States Senator in Ohio in the 2022 Senate race, replacing retiring Republican Senator Rob Portman.[6] He official announced his candidacy in late April 2021.[7] In May 2022, Ryan won the Democratic nomination for the Senate.[8] He lost the election in November to J. D. Vance.