The player can play as all three Powerpuff Girls and seven villains. One player can either be a villain or a Powerpuff Girl and the second player can only play as a villain. When the characters collect enough bottles of Chemical X, they use their superpowers. The PlayStation port gives an extra superpower to all three Powerpuff Girls.
Playable characters
Blossom
Bubbles
Buttercup
Ace
Big Billy
Sedusa
Princess Morbucks
Fuzzy Lumpkins
Mojo Jojo
HIM
Plot
The Powerpuff Girls decided to make a pie filled with Chemical X. As they left it by the window to cool, Mojo Jojo stole it and shared it with the other villains. The girls didn't see the pie once they returned to the kitchen. Bubbles told Blossom and Buttercup she added Chemical X to the pie so that it would be super. They figured out that Mojo Jojo has taken the pie. After defeating the villains and Mojo Jojo, HIM offered a challenge to his lair.
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