Spider-Man 2099 (real name Miguel O'Hara) is a fictional character and superhero in the Marvel Comics universe, and is a superhero hailing from the future, specifically the year 2099, and the successor of the original Spider-Man, Peter Parker. He was created by Peter David and Rick Leonardi, and first appeared in Spider-Man 2099 #1 in March of 1992. He is also the main protagonist of his titular comics, and a major character in the Spider-Verse comics storyline.

He is a geneticist working for Alchemax who, in an attempt to replicate the powers of Spider-Man, accidentally altered his genetic code to 50% spider, giving him spider-like superpowers. Miguel originally strived to find a cure, but upon realizing how much of a dystopia the future was, donned a UMF-crafted suit and became the next Spider-Man. He is the eponymous protagonist of the comic book of the same name, and is a supporting protagonist in various Spider-Man stories, especially the Spider-Verse storyline.

The character has appeared in numerous media adaptations, while making his cinematic debut in the animated movie Spider-Man: Into the Spider-Verse (2018), where he was voiced by Oscar Isaac in the movie's post-credits scene. The character also appears in the movie's sequel, Spider-Man: Across the Spider-Verse (2023), with Isaac reprising the role.