Southern Zone Zoba Debub ዞባ ደቡብ المنطقة الجنوبية Regione del Sud
Zoba
Debub Region in Eritrea
Coordinates: 14°48′N 39°00′E / 14.800°N 39.000°E / 14.800; 39.000
Country	Eritrea
Capital	Mendefera
Area
• Total	8,000 km2 (3,000 sq mi)
Population
• Total	1,476,765
• Density	180/km2 (480/sq mi)
ISO 3166 code	ER-DU

Southern Region is a region of Eritrea. It is also known as Debub Region. The capital city is Mendefera. The region was formed on 15 April 1996, from the historical provinces of Serae and Akele Guzai.

Mount Soira 3,018 m (9,902 ft), the highest point in Eritrea, is in the region.

The region has the following subregions:

• Adi Keyh Subregion
• Adi Quala Subregion
• Debarwa Subregion
• Dekemhare Subregion
• Hadidia Subregion
• Kudo Be'ur Subregion
• Mai-Mne Subregion
• Mendefera Subregion
• Segeneiti Subregion
• Senafe Subregion
• Tera-Emni Subregion
• Tsorona Subregion
• Shiketi Subregion