Espy was indicted in 1997 for receiving improper gifts, but acquitted of all 30 charges in 1998.
On March 5, 2018, Epsy announced his candidacy for Thad Cochran's U.S. Senate seat in the wake of Cochran's retirement.[2] On November 6, 2018, Espy and Republican Cindy Hyde-Smith advanced to a run-off election where he lost to Hyde-Smith.[3]
On November 30, 2018, Epsy filed to run again Hyde-Smith again for the 2020 election.[4] He won the Democratic nomination again in March 2020. He lost the election again to Hyde-Smith in November 2020.